Search results for "bottom-up approach"
showing 7 items of 7 documents
The Role of Mathematical Models in Immuno-Oncology: Challenges and Future Perspectives
2021
Immuno-oncology (IO) focuses on the ability of the immune system to detect and eliminate cancer cells. Since the approval of the first immune checkpoint inhibitor, immunotherapies have become a major player in oncology treatment and, in 2021, represented the highest number of approved drugs in the field. In spite of this, there is still a fraction of patients that do not respond to these therapies and develop resistance mechanisms. In this sense, mathematical models offer an opportunity to identify predictive biomarkers, optimal dosing schedules and rational combinations to maximize clinical response. This work aims to outline the main therapeutic targets in IO and to provide a description …
A bottom-up approach for the evaluation of the flexible quota of aggregated loads
2015
The paper presents a bottom-up approach for building the aggregated load profile of numerous passive/active users connected to the low voltage electrical system. The approach is based on the Monte Carlo method and on the knowledge of the single electric and thermal loads, generators and thermal and geometrical characteristics of the building of the single end-user. The method proposed is able to differentiate the quota of flexible and not flexible aggregate load.
Strategic Vision of a Euro-Mediterranean Port City: A Case Study of Palermo
2013
Italian harbours assume a decisive role in order to develop a Euro-Mediterranean web for maritime transportation. The geostrategic position of the Italian peninsula can be seen as a logistic platform at the centre of the maritime trades in the Mediterranean area, giving to its port cities the role of gateway of economic flows. The port poles, meant as hubs, are able to attract investments and create economic growth and territorial development through new operative models of urban usage and management. The management policies have to consider the environmental characteristics and distinctive features, respecting the identity of the places as concrete evidence of history, a source of intellec…
A bottom-up harmonized energy-environmental models for europe (BOHEEME): A case study on the thermal insulation of the EU-28 building stock
2021
Abstract The paper presents a methodological approach, called “BOttom-up Harmonized Energy-Environmental Models for Europe” (BOHEEME), that combines bottom-up modeling, energy dynamic simulation, and life cycle assessment for evaluating and comparing the energy and environmental effects of different renovation strategies of the residential EU building stocks, from micro to the macro level. The study defines 672 building models representative of the residential EU-28 building stocks built before 2010, called archetypes, and the improvement of their envelope, applying different insulation materials from a traditional one to bio-based materials and studying their environmental effects via LCA.…
Il fondamento effimero : seminario residenziale di allestimento urbano e architettura effimera, Tonezza del Cimone, 25-31 Agosto 2018
2019
Tourist places often suffer a fate that sees them seasonally abandoned, so that their image drastically changes over the course of the year, generating gaps that need an identity rather than waiting for the festive mass passing by. Professors, students, teacher assistants collaborated together in a weekly on-site workshop meeting and listening people resident with a bottom-up approach.
Spray dried hyaluronic acid microparticles for adhesion controlled aggregation and potential stimulation of stem cells
2017
Spray-dried microparticles of a derivative of hyaluronic acid (HA) have been engineered to obtain a controlled aggregation with Human Mesenchymal Stem Cells (hMSCs) into 3D constructs. We demonstrated the utility of chemical functionalization of a native constituent of the extracellular matrix to improve processing performances and to control on stem cell adhesion and differentiation. Native hyaluronic acid (HA), cell adhesive peptides (RGD), transforming growth factor β3, dexamethasone are biological agents potentially suitable for chondrogenic stimulation of hMSCS. However unmodified HA suffers of drawbacks in terms of stability and versatility of processing. Functionalization strategies…
Biochar and Forage Peanut improve pastures: Evidence from a field experiment in Brazil
2023
Pasturelands, often degraded, represent most of the converted lands globally. It is important to understand how different pasture management approaches can improve soil quality, increase feed production and farmer income. Here, the impact of different soil enhancers on soil quality and productivity of three cultivars of Brachiaria (Syn. Urochloa) forage grass is presented. Soil enhancers included: biochar - a carbon-rich product from biomass pyrolysis, moinha (local charcoal residue), traditional fertiliser containing nitrogen, phosphorus and potassium, lime, and forage peanut (Arachis pintoi cv. Amarillo). Considering the total biomass produced over the experiment (sum of four harvests), t…